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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CDB-2914
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
126784-99-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥605.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥550.0 |
| 规格： | 10 mg | 产品价格： | ￥770.0 |
| 规格： | 50 mg | 产品价格： | ￥1900.0 |
| 规格： | 100 mg | 产品价格： | ￥2900.0 |
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Ulipristal acetate
CAS No. : 126784-99-4
MCE 国际站：Ulipristal acetate
产品活性：Ulipristal acetate (CDB-2914) 是一种口服活性的选择性孕酮受体 (progesterone receptor) 调节剂 (SPRM)。Ulipristal acetate 选择性地刺激平滑肌瘤细胞的自噬反应。Ulipristal acetate 具有用于良性妇科疾病的潜力，如子宫肌瘤。
研究领域：Vitamin D Related/Nuclear Receptor | Autophagy
作用靶点：Progesterone Receptor | Autophagy
In Vitro: Ulipristal acetate (0.1-5 μM; 96 hours) stimulates autophagy in leiomyoma cells. Ulipristal-induced expression changes of the autophagic markers LC3 and p62/SQSTM1. Ulipristal up-regulates Atg7 protein in leiomyoma cells.
Ulipristal acetate blocks activin A modulation of fibronectin and vascular endothelial growth factor A (VEGF-A) mRNA expression in cultured myometrial and leiomyoma cells.
In Vivo: Ulipristal and CDB-4124 have significant antiprogestational activity in vivo.
Ulipristal acetate decreases incidences of fibroadenomas and adenocarcinomas in the mammary gland in all treated groups. Ulipristal acetate exposure [AUC(0-24h)] at the highest dose in rats is 67 times human therapeutic exposure at 10 mg/day. In mice, no tumor of any type increases at Ulipristal acetate exposures up to 313 times of therapeutic exposure. Ulipristal acetate-related findings in mice are limited to organ weight changes in the liver, pituitary, thyroid/parathyroid glands, and epididymis as well as minimal panlobular hepatocellular hypertrophy in male and female mice receiving 130 mg/kg/day.
Ulipristal acetate (1 mg/kg and 5 mg/kg) increases the frequency with which pathologists assessed the endometrium as being thickened compared to controls in a dose-dependent manner. There is a slight decrease in secretory differentiation with increasing dose of Ulipristal acetate, with small decreases in frequency of sub- and supra-nuclear vacuolation.
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hybridization, in situ PCR and in situ 3SR techniques were born. Silver Acetate AMG was developed and optimized during research visits of Gerhard W. HACKER at the University of Uppsala, Sweden, in joint collaboration with Gorm DANSCHER (Aarhus, DK) and Lars
Sodium Acetate Precipitation of Small Nucleic Acids
实验步骤 1. Add 2 μl carrier to the nucleic acid solution and mix well. 2. Add 1:10 volume of 3 M sodium acetate and mix thoroughly; for 230 μl of Lower Running Buffer, this will be 23 μl of 3 M
Acetate Kinase From Methanosarcina thermophila, a Key Enzyme for Methanogenesis
Materials and procedures are described for the overproduction and purification of acetate kinase from Methanosarcina thermophila. Methods are detailed for large-scale preparation of the unaltered enzyme and for overproduction and one-step
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