Istaroxime

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Istaroxime

CAS No. : 203737-93-3

MCE 国际站：Istaroxime

产品活性：Istaroxime (PST2744) 是一种有效的 Na⁺,K⁺-ATPase 抑制剂，IC₅₀ 值为 0.11 μM。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Na+/K+ ATPase

In Vitro: Istaroxime acting as a positive inotropic compound through the inhibition of the Na⁺,K⁺-ATPase. Istaroxime (PST2744) inhibits the Na⁺/K⁺-ATPase activity from dog kidney with an IC₅₀ value of 0.43 ± 0.15 μM. Inhibition of Na⁺/K⁺-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744.

In Vivo: Istaroxime (PST2744) induces a progressive increase in +dP/dt_max throughout the infusion that reaches 80% (ED₈₀) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED_max) of 4.88±0.6 mg/kg.

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