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- MedChemExpress(MCE)
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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1207360-89-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥666.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥294.0 |
| 规格： | 5 mg | 产品价格： | ￥669.0 |
| 规格： | 10 mg | 产品价格： | ￥1068.0 |
| 规格： | 25 mg | 产品价格： | ￥2240.0 |
| 规格： | 50 mg | 产品价格： | ￥3360.0 |
| 规格： | 100 mg | 产品价格： | ￥4963.0 |
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GDC-0349
CAS No. : 1207360-89-1
MCE 国际站：GDC-0349
产品活性：GDC-0349 是一种有效的，ATP竞争性的选择性 mTOR 抑制剂，Ki 值为 3.8 nM。GDC-0349 抑制 mTORC1 和 mTORC2 复合体。
研究领域：PI3K/Akt/mTOR | Autophagy
In Vitro: GDC-0349 (Compound 8h) is a remarkably selective mTOR inhibitor, with less than 25% inhibition of 266 kinases, including all isoforms of PI3K when tested at 1 μM.
In Vivo: When dosed orally once daily in athymic mice in a MCF7-neo/Her2 tumor xenograft model (PI3K mutation), GDC-0349 (Compound 8h) inhibits tumor growth in a dose-dependent manner, achieving stasis (99% TGI) at the maximum tolerated dose. Body weight change is less than 10% up to the highest dose. GDC-0349 is also efficacious in other xenograft models, including PC3 (PTEN null) and 786-0 (VHL mutant). Similar levels of tumor growth inhibition are achieved when GDC-0349 is administered once every three days at higher doses compared to once every day. GDC-0349 has ~10-fold reduced free plasma clearance in both mice (100 mL/min/kg) and rats (171 mL/min/kg in rat).
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