Naproxen萘普生钠,26159-34-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Naproxen sodium

CAS No. : 26159-34-2

MCE 国际站：Naproxen sodium

产品活性：Naproxen sodium 是COX-1 和 COX-2 的抑制剂，在细胞试验中 IC₅₀ 值分别为8.72和5.15 μM。

研究领域：Autophagy  |  Immunology/Inflammation

作用靶点：Autophagy  |  COX

In Vitro: Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC₅₀s of 2.2 μg/mL and 1.3 μg/mL, respectively.

In Vivo: Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC₅₀=27, 40, 13 μM).

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Rare Diseases Drug Library  |  Anti-Colorectal Cancer Compound Library   |  Children’s Drug Library  |  Antidepressant Compound Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Non-steroidal Anti-Inflammatory Compound Library  |  Off-patent Drug Library  |  Cell Death Library  |  Acetaminophen  |  Indomethacin  |  Celecoxib  |  EIPA  |  Aspirin  |  Oxidopamine hydrobromide  |  Deferiprone  |  Diclofenac  |  Gallic acid  |  Ibuprofen  |  Catechin  |  20(S)-Ginsenoside Rg3  |  Cucurbitacin B  |  Carprofen  |  Meloxicam  |  (-)-Epicatechin  |  NS-398  |  Naproxen  |  Xanthohumol  |  Flufenamic acid  |  Salicylic acid  |  Phenacetin  |  Ketoprofen  |  SC-560  |  Rebamipide  |  Ginsenoside Rd

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds