- ￥2753 - 3813
- MedChemExpress(MCE)
- 美国
- HY-14775
- 2025年07月11日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
HCV-796
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
691852-58-1
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3028.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2753.0 |
| 规格： | 10 mg | 产品价格： | ￥3813.0 |
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Nesbuvir
CAS No. : 691852-58-1
MCE 国际站：Nesbuvir
产品活性：Nesbuvir 是一种非核苷抑制剂，抑制丙型肝炎病毒(HCV) 非结构蛋白 5B (NS5B) 聚合酶。
研究领域：Anti-infection
作用靶点：HCV
In Vitro: Replicon cells are treated with 1 mg/mL G418 and combinations of the two compounds. Nesbuvir (HCV-796) is added to 40 or 80 nM (approximately 10 and 20 times the EC50 in a 3-day replicon inhibition assay, respectively) and Boceprevir is added to 400 or 800 nM (approximately 2 and 4 times the EC50, respectively). The EC50s for Nesbuvir and Boceprevir for the parental replicon in the transient expression assay are comparable to those obtained in the 3-day inhibition assay with the stable replicon cells; the EC50 for Nesbuvir in the transient expression assay is 14 nM, whereas it is 5 nM for the stable replicon; and the EC50 for Boceprevir in the transient expression assay is 608 nM, whereas it is 201 nM for the stable replicon.
In Vivo: Among a huge variety of yet characterized nucleoside and non-nucleoside inhibitors (NNI), the benzofurane derivative NNI Nesbuvir (HCV-796) is demonstrated to yield significant antiviral effects in mice with chimeric human livers and in patients infected with HCV. HCV-796 binds to a hydrophobic binding pocket at the “palm” domain of NS5B; however, its mode of inhibition remains to be defined.
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