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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CGS 20267
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥715.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥650.0 |
| 规格： | 50 mg | 产品价格： | ￥900.0 |
| 规格： | 100 mg | 产品价格： | ￥1600.0 |
| 规格： | 200 mg | 产品价格： | ￥2800.0 |
| 规格： | 500 mg | 产品价格： | ￥4100.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Letrozole
CAS No. : 112809-51-5
MCE 国际站：Letrozole
产品活性：Letrozole (CGS 20267) 是一种有效的，选择性的，可逆的和具有口服活性的非甾体类芳香化酶 (aromatase) 抑制剂，IC50 值为 11.5 nM。Letrozole 选择性抑制雌激素的生物合成，可用于乳腺癌的研究。
研究领域：Metabolic Enzyme/Protease | Autophagy
作用靶点：Cytochrome P450 | Autophagy
In Vitro: Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner.
Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation.
Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells.
In Vivo: Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats.
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