Amiodarone hydrochloride

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Amiodarone hydrochloride

CAS No. : 19774-82-4

MCE 国际站：Amiodarone hydrochloride

产品活性：Amiodarone hydrochloride是一种 III 类抗心律失常剂，可抑制野生型IhERG 钾通道及其尾电流，IC₅₀ 约为 45 nM。Amiodarone hydrochloride通过成纤维细胞中，Amiodarone hydrochloride ERK1/2 和p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化。Amiodarone hydrochloride可用于室上性和室性心律失常的研究。

研究领域：Membrane Transporter/Ion Channel  |  Autophagy

作用靶点：Potassium Channel  |  Autophagy

In Vitro: Amiodarone blocks inward IhERG tails in a high K⁺ external solution ([K⁺]e) of 94 mM with an IC₅₀ of 117.8 nM.
?Amiodarone (1 μM) blocks inwardIhERG by 68.8±6.1%, with concentration response data yielding IC₅₀ and h values of 765.5±287.8 nM and 0.9±0.4 for T623A hERG.
?Amiodarone (1 μM) blocks inward IhERG with an IC₅₀ and h values of 979.2±84.3 nM and 1.1±0.1 for S624A hERG.
?Amiodarone (1-6?μg/mL) induces human embryonic lung fibroblasts (HELFs) cell proliferation and PD98059 or SB203580 suppresses this effect.
?Amiodarone (1-6?ug/mL) does not induces HELFs cell apoptosis. Amiodarone (over 15?ug/mL) induces cell apoptosis.
?Amiodarone (1, 3 and 6?μg/mL;24?hours) induces α-SMA and vimentin mRNA and protein expression accompanied by increased phosphorylation of ERK1/2 and p38 MAPK.

In Vivo: Amiodarone hydrochloride can be used in animal modeling to construct animal models of pulmonary fibrosis.

Long-term Amiodarone (90, and 180 mg/kg/day) treatment induces a dose-dependent remodeling of ion-channel expression that is correlated with the cardiac electrophysiologic effects of Amiodarone.

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