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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
盐酸利莫那班
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
158681-13-1
- 规格：
10 mM * 1 mL/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥638.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥580.0 |
| 规格： | 50 mg | 产品价格： | ￥2000.0 |
| 规格： | 100 mg | 产品价格： | ￥3000.0 |
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Rimonabant Hydrochloride
CAS No. : 158681-13-1
产品活性：Rimonabant hHydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
研究领域：GPCR/G Protein | Neuronal Signaling | Anti-infection
作用靶点：Cannabinoid Receptor | Bacterial
In Vitro: Rimonabant could inhibit the growth of Mtb with an MIC of 54 μM. MmpL3, an anti-TB target, is the direct target of rimonabant.
Rimonabant itself (10-12-10-3 M, 12 concentrations) inhibits the basal binding of [35S]GTPgS to human cortical membranes in a concentration dependent manner, with a -log IC50 of 4.7±0.2 (IC50 = 20 μM) and a maximal inhibition of 48±2%.
In Vivo: Rimonabant (10 mg/kg by gavage) is fed for 2 weeks to 3-month-old male obese Zucker rats as an impaired glucose tolerance model and for 10 weeks to 6-month-old male obese Zucker rats as a model of the metabolic syndrome. RANTES and MCP-1 serum levels are increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with Rimonabant, which slowes weight gain in rats with the metabolic syndrome. Neutrophils and monocytes are significantly increased in young and old obese vs lean Zucker rats and lowered by Rimonabant. Platelet-bound fibrinogen is significantly enhanced in obese vs lean Zucker rats of both age, and is reduced by Rimonabant .
Rimonabant (20 mg daily) exhibits a significant reduction in many cardiometabolic risk factors.
相关产品：FDA-Approved Drug Library Plus | Drug Repurposing Compound Library | Anti-Infection Compound Library | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Anti-Bacterial Compound Library | Puromycin Dihydrochloride | Tunicamycin | CCCP | G-418 disulfate | Doxycycline (hyclate) | Hygromycin B | Bleomycin sulfate | Streptozocin | Neomycin sulfate | Vancomycin hydrochloride | Ampicillin sodium | Auranofin | Avibactam sodium | Rifampicin | Salinomycin | Vaborbactam | E-64 | Gentamicin sulfate | Eravacycline dihydrochloride | Geldanamycin | Carbenicillin disodium | Minocycline hydrochloride | Kanamycin sulfate | Metronidazole | Ceftazidime | Probenecid | Ciprofloxacin | Omadacycline hydrochloride | Cefiderocol | Delamanid
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文献和实验Health Evaluation of Experimental Laboratory Mice
Clark, M.D., Krugner‐Higby, L., Smith, L.J., Heath, T.D, Clark, K.L., and Olson, D. 2004. Evaluation of liposome‐encapsulated oxymorphone hydrochloride in mice after splenectomy. Comp. Med. 54:558‐563
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