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1-Naphthyl PP1
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
1-NA-PP 1
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
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CAS No. : 221243-82-9
MCE 国际站:1-Naphthyl PP1
产品活性:1-Naphthyl PP1 (1-NA-PP 1) 是一种选择性的 src 家族激酶和蛋白激酶 D 抑制剂。1-Naphthyl PP1 抑制 v-Src 和 c-Fyn,c-Abl,CDK2 和CAMK II,IC50 分别为 1.0,0.6,0.6,18 和 22 μM。
研究领域:Protein Tyrosine Kinase/RTK | Apoptosis
作用靶点:Src | PKD
In Vitro: 1-Naphthyl PP1 inhibits PKD1, 2, and 3 with IC50s of 154.6 nM, 133.4 nM, 109.4 nM respectively.1-Naphthyl PP1 (0-70 μM, 45 min) inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced autophosphorylation at p-Ser916-PKD1 in LNCaP cells with an IC50 of 22.5 µM.1-Naphthyl PP1 (0-100 μM, 72 h) inhibits PC3 cell proliferation, survival, and arrested cells in G2/M (10 μM, 48 h).
In Vivo: 1-Naphthyl PP1 (30 mg/kg, i.p.) reversibly reduces ethanol consumption by ATP analog-specific PKCε (AS-PKCε) mice.
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