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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Atavaquone
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
95233-18-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥156.0 |
| 规格： | 5 mg | 产品价格： | ￥312.0 |
| 规格： | 10 mg | 产品价格： | ￥500.0 |
| 规格： | 25 mg | 产品价格： | ￥890.0 |
| 规格： | 50 mg | 产品价格： | ￥1500.0 |
| 规格： | 100 mg | 产品价格： | ￥2220.0 |
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Atovaquone
CAS No. : 95233-18-4
MCE 国际站：Atovaquone
产品活性：Atovaquone (Atavaquone) 是一种有效的、具有口服活性的选择性寄生虫线粒体细胞色素 bc1 (parasite’s mitochondrial cytochrome bc1) 复合物的抑制剂。Atovaquone 抑制人类和 P. falciparum 细胞色素 bc1 活性，IC50 值分别为 460 nM 和 2.0 nM。Atovaquone 是一种抗疟 (antimalarial agent) 试剂，有潜力用于肺孢子虫肺炎、弓形体病、疟疾和巴贝斯虫病的相关研究。
研究领域：Anti-infection | Metabolic Enzyme/Protease
作用靶点：Parasite | Cytochrome P450 | Antibiotic | Bacterial
In Vitro: Atovaquone targets to the Qo?site of the?Plasmodium?cytochrome?bc1?complex of the mitochondrial electron transport chain.
Atovaquone is against the development in the mosquito from gamete production, through fertilization, zygote formation and finally, to the development of the mature ookinete, and demonstrates an IC50?of 67 nM providing further evidence of the transmission blocking potential of this molecule.
In Vivo: Atovaquone (oral administration; 100 mg/kg; once daily) is against survival rates of mice, mice treated orally died within 22 days after discontinuation of sulfadiazine,while the control group died at day 14.
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文献和实验疟原虫 Malaria Parasites(Plasmodium)
from: Coatney GR, Collins WE, Warren M, Contacos PG. The Primate Malarias. U.S. Department of Health, Education and Welfare, Bethesda, 1971.Fig. 1: Normal red cell; Figs. 2-6: Young trophozoites (ring stage parasites); Figs. 7-18: Trophozoites; Figs
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