Pimecrolimus吡美莫司,137071-32-0

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Pimecrolimus

CAS No. : 137071-32-0

MCE 国际站：Pimecrolimus

产品活性：Pimecrolimus (SDZ-ASM 981) 是一种有效的、非甾体和具有口服活性的钙调磷酸酶 (calcineurin) 抑制剂，K_i 值为 117 nM。Pimecrolimus 显示出抗炎活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: Pimecrolimus (SDZ-ASM 981) (100 nM) targets T-cells and mast cells and inhibits the production and release of cytokines and other inflammatory mediators, as well as the expression of signals essential for the activation of inflammatory T-lymphocytes.
Pimecrolimus acts specifically on cells that are crucial for the effector phase of an inflammatory reaction.
Pimecrolimus (10 nM; 3 days) inhibits the polyclonal growth of peripheral blood T cells in murine and human mixed lymphocyte reactions.
Pimecrolimus inhibits cytokine IL-2, IL-4, IL-10 and interferon-γ release from T-cell clone CFTS4:3.1 with IC₅₀s of 0.28, 0.3, 0.2 and 0.42 nM, respectively after antigen-specific stimulation.

In Vivo: Pimecrolimus (SDZ-ASM 981) (0-0.4%; topical; 10 μL once) inhibits allergic contact dermatitis in mice and pigs.
Pimecrolimus (0-90 mg/kg; p.o. or s.c.; twice or once) potently inhibits allergic contact dermatitis in mice and rats.

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