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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
892549-43-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1210.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 50 mg | 产品价格： | ￥7200.0 |
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MF63
CAS No. : 892549-43-8
MCE 国际站：MF63
产品活性：MF63 是一种具有口服活性的 mPGES-1 抑制剂。MF63 通过抑制 mPGES-1 减少了 PGE2 的积累，缓解了发热、痛觉过敏和炎性疼痛。
作用靶点：PGE synthase
In Vitro: MF63 (0.01-100 µM; 24 h) selectively inhibits PGE2 induced by 10 ng/mL IL-1β in A549 cells, and increases the formation of PGF2α in a dose-dependent manner.
MF63 (10 µM; 24 h) enhances the expression of various metallothionein 1 (MT1) subtypes and endogenous antagonists of IL-1 and IL-36 with the anti-inflammatory effects.
In Vivo: MF63 (100 mg/kg; p.o.; single dose) attenuates PEG2 accumulation in air pouches and brains of the KI (knock-in mPGES-1 gene) mice and inhibits PEG2 formation in a dose-dependent manner.
MF63 (10 mg/kg and 100 mg/kg; p.o.; single dose) inhibits the hyperalgesic response induced by LPS in the KI mice, with dose-dependently manner.
MF63 (0-150 mg/kg; p.o.; single dose) inhibits PEG2 synthesis, hyperalgesia, pyresis and relieves Chronic Osteoarthritic-Like Pain in the guinea pig.
MF63 (0-100 mg/kg; p.o.; twice daily for 4 days) has gastrointestinal tolerability in KI mice and nonhuman primates.
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