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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
57477-39-1
- 规格：
10 mM * 1 mL/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥788.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥716.0 |
| 规格： | 50 mg | 产品价格： | ￥2930.0 |
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BRL 54443
CAS No. : 57477-39-1
MCE 国际站：BRL 54443
产品活性：BRL 54443 是 5-HT1E/1F 受体激动剂，Ki 分别为 1.1 nM 和 0.7 nM，比对其它 5-HT 和多巴胺受体的抑制性高 30 倍以上。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：5-HT Receptor
In Vitro: Despite its low affinity for other receptors [5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM)], BRL54443 binds with high affinity at 5-HT1F receptors.
In DG membranes, BRL54443 selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production (IC50=14 nM). BRL 54443 also induces contraction (-log EC50=6.52).
In Vivo: Reduction of flinching was considered as antinociception. Ipsilateral, but not contralateral, peripheral administration of BRL54443 (5-HT(1E/1F); 3-300 microg/paw) significantly reduced formalin-induced flinching in rats.
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文献和实验Protocol for competitive RT-PCR
that containes a T7 RNA promoter sequence. The in vitro transcription of the cloned fragments is performed using T7 RNA polymerase (e.g. Gibco BRL). The internal standard RNA is then treated with RNase-free DNase I (e.g. Gibco BRL) to remove the plasmid DNA
DNA Preparation from Adherent Cells
Section of Cancer Genomics,Genetics Branch,NCI National Institutes of Health Reagents Chloroform Mallinckrodt,cat.4440 EDTA,0.5 M Ethanol,100% Ethanol,70% Isoamyl Alcohol Sigma,cat.I-3643 Phenol Gibco BRL,Cat.15513-039 Phosphate Buffered
You will need for 1° cDNA synthesis: 5 x SuperScript RTase buffer (Gibco-BRL) 5mM methyl dNTPs (Pharmacia, substitute 5m dCTP for dCTP) 100mM DTT (Gibco-BRL) oligo dT primer/adaptor [a-32P] dATP (~400Ci/mmol, Amersham or DuPont) Ribonuclease inhibitor
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