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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
124431-80-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1031.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥397.0 |
| 规格： | 5 mg | 产品价格： | ￥874.0 |
| 规格： | 10 mg | 产品价格： | ￥1260.0 |
| 规格： | 50 mg | 产品价格： | ￥4650.0 |
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CGS 21680 Hydrochloride
CAS No. : 124431-80-7
MCE 国际站：CGS 21680 Hydrochloride
产品活性：CGS 21680 Hydrochloride 是选择性的 adenosine A2A receptor 激动剂，Ki值为为 27 nM。
研究领域：GPCR/G Protein
作用靶点：Adenosine Receptor
In Vitro: CGS21680 significantly upregulates CD39 and CD73 expression. CGS21680 accelerates the adenosine triphosphate (ATP) hydrolysis and adenosine generation. CGS21680 (10 nM) alone shows only small survival activity, but the activity is significantly enhanced by the addition of a phosphodiesterase inhibitor, IBMX. The survival activity of CGS21680 on cultured motoneurons is exerted by mixed effects of the adenylate cyclase-cAMP-PKA pathway and the transactivation of neurotrophin receptors.
In Vivo: CGS21680 (1 mg/kg/i.p.) intervention promotes the development of EAN. CGS21680 exacerbates experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin. The exacerbation is accompanied with reduced CD4+ Foxp3+ T cells, increased CD4+ CXCR5+ T cells, B cells, dendritic cells and antigen-specific autoantibodies, which is possibly due to the inhibition of IL-2 induced by CGS21680. CGS21680 (0.1 mg/kg, i.p.) transiently increases heart frequency but does not modify blood pressure of rat, and does not modify either heart frequency or blood pressure at 0.01 mg/kg. Following transient MCAo, CGS21680 at both doses protects from neurological deficit from the first day up to 7 days thereafter. At this time, it has reduced microgliosis, astrogliosis and improved myelin organization in the striatum and cytoarchitecture of the ischemic cortex and striatum. Two days after transient MCAo, CGS21680 has reduced the number of infiltrated granulocytes into the ischemic tissue.
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文献和实验Southern Analysis Using Methyl-Sensitive Restriction Enzymes
for Southern blotting, thereby reducing its usefulness in the study of DNA methylation in the female germline and preimplantation embryos. Second, the analysis is limited to CGs that occur in a DNA sequence context that is recognized by a methyl-sensitive
Animal Models of Anxiety and Depression
15–1788 [flumazeml]), partial agonists (e.g., CGS 98961, and inverse agonists (e.g., B-CCM). For reviews see Thlebot (1983); La1 and Emmett-Oglesby (1983); File (1984;1985;1987); Crawley (1985); Treit (1985a;1994); Shephard (1986); Gardner (1988
Characterization of P1 (Adenosine) Purinoceptors
Introduction Basic Protocol 1: Determination of [3H]CHA Binding to A1 Receptors Basic Protocol 2: Determination of [3H]CGS 21680 Binding to A2A Receptors Basic Protocol
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