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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
R788
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1277.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥454.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
| 规格： | 25 mg | 产品价格： | ￥3000.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Fostamatinib
CAS No. : 901119-35-5
MCE 国际站：Fostamatinib
产品活性：Fostamatinib (R788) 是 R406 的口服前体。R406 是一种有效的，具有口服活性的，ATP 竞争性的 Syk/FLT3 抑制剂，Ki 为 30 nM，IC50 为 41 nM。R406 还抑制 Lyn (IC50=63 nM) 和 Lck (IC50=37 nM).
研究领域：Protein Tyrosine Kinase/RTK
In Vivo: Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ng*h/mL and 30650 ng*h/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Antiviral Compound Library | Drug Repurposing Compound Library | Anti-diabetic Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Blood Cancer Compound Library | Rare Diseases Drug Library | EMA-Approved Drug Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Cytokine Inhibitors Library | Sorafenib | Cabozantinib | Gilteritinib | Quizartinib | Pacritinib | Crenolanib | R406 | Linifanib | Emavusertib | Rebastinib | Piceatannol | Ripretinib | AT9283 | Dovitinib | Entospletinib | KW-2449 | Sitravatinib | (E/Z)-Zotiraciclib | UNC2025 | Gandotinib | Merestinib | PRT062607 Hydrochloride | Cerdulatinib | CHIR-124 | TG101209 | Fostamatinib Disodium
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