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- 2025年07月14日
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- 详细信息
- 询价记录
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
ACT 078573
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
871224-64-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1635.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥457.0 |
| 规格： | 5 mg | 产品价格： | ￥1450.0 |
| 规格： | 10 mg | 产品价格： | ￥2450.0 |
| 规格： | 50 mg | 产品价格： | ￥8550.0 |
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Almorexant
CAS No. : 871224-64-5
MCE 国际站：Almorexant
产品活性：Almorexant (ACT 078573) 是一种口服有效且竞争性的双 orexin receptor 拮抗剂，Kd 分别为 1.3 nM (OX1) 和 0.17 nM (OX2)。Almorexant 可逆地阻断食欲素-A 和食欲素-B 多肽信号。Almorexant 完全阻断细胞内 Ca2+ 信号通路。Almorexant 刺激 AsPC-1 细胞 caspase-3 活性，诱导细胞凋亡 (apoptosis)。
研究领域：GPCR/G Protein | Neuronal Signaling | Membrane Transporter/Ion Channel | Apoptosis
作用靶点：Orexin Receptor (OX Receptor) | Calcium Channel | Caspase | Apoptosis
In Vitro: Almorexant (1 μM) promotes tyrosine phosphorylation of SHP2/OX1R complex.
Almorexant (1 μM) inhibits the cellular growth of AsPC-1 cells.
In Vivo: Almorexant (1.8 μmol/kg, 100 μL; IP, daily) reduces the volume of tumors.
Almorexant (300 mg/kg, PO, once) can help rats to be fully capable of spatial and avoidance learning.
Almorexant (30-300 mg/kg) dose-dependently increases rapid eye movement (REM) and non-REM (NREM) sleep and decreases wakefulness apparently without inducing either cataplexy18 or deficits in next-day performance.
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