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- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
BMS-512148
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
461432-26-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥825.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥750.0 |
| 规格： | 10 mg | 产品价格： | ￥1100.0 |
| 规格： | 50 mg | 产品价格： | ￥2750.0 |
| 规格： | 100 mg | 产品价格： | ￥4500.0 |
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Dapagliflozin
CAS No. : 461432-26-8
MCE 国际站：Dapagliflozin
产品活性：Dapagliflozin (BMS-512148) 是一种竞争性葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，可导致尿液中葡萄糖的排泄，用于糖尿病 (DM) 的研究。Dapagliflozin 诱导 HIF1 表达并减轻肾脏 IR 损伤。
研究领域：Membrane Transporter/Ion Channel
作用靶点：SGLT
In Vitro: Dapagliflozin (0-10 μM；24 hours) significantly increases the cell survival in hypoxic HK2 cell in a dose-dependent manner.
Dapagliflozin (0-10 μM；2 hours) increases the HIF1 expression, increases AMPK and EKR phosphorylation in hypoxic HK2 cells, but shows no effect on the phosphorylation of AMPK and ERK in normoxic HK2 cells..
In Vivo: Dapagliflozin (oral administration; 10 mg/kg) causes a marked increase in urinary glucose in SGLT2i-mice, suppresses BAT thermogenesis by reducing sympathetic nerve activity and enhances hepatic gluconeogenesis and glycogenolysis.
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