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文献和实验Measuring DNA Adducts by Immunoassay (ELISA)
A large proportion of anti-cancer drugs act by causing chemical modifications to DNA, often involving the addition of part of the drug molecule to DNA to form DNA adducts. As discussed in Chapter 1 , resistance mechanisms can act to diminish
Biolistic DNA Vaccination Against Cervical Cancer
targets for anti-tumor immunization. To adapt the corresponding genes for DNA vaccination, their oncogenicity needs to be reduced and immunogenicity enhanced. The main modifications for achieving these aims include mutagenesis, rearrangement of gene parts
Transcriptional Footprinting of DrugDNA Interactions
binding (e.g., distamycin), formation of adducts or crosslinks (e.g., melphalan, cisplatin, mitomycin C), or by incorporation of modified bases (e.g., 5-fluorouracil, 6-thioguanine). There has therefore been a great effort over many years to establish
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