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Anti-PD-L1 Antibody, clone 10F

.9G2
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  • 询价
  • merck-millipore
  • MABC991
  • 2026年02月19日
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    北京盛科博源生物科技有限公司
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    • 供应商：

      北京盛科博源生物科技有限公司

    • 规格：

      100 μg

    Key Specifications Table

    Species Reactivity Key Applications Host Format Antibody Type
    M FC, Inhibition, IHC R Purified Monoclonal Antibody
    Description
    Catalogue Number MABC991
    Replaces MABF405
    Description Anti-PD-L1 Antibody, clone 10F.9G2
    Alternate Names
    • PD-L1
    • PDCD1 ligand 1
    • Programmed death ligand 1
    • B7 homolog 1
    • B7-H1
    • CD274
    Background Information Programmed cell death 1 ligand 1 (UniProt: Q9EP73; also known as PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274) is encoded by the CD274 (also known as B7h1, Pdcd1l1, Pdcd1lg1, Pdl1) gene (Gene ID: 60533) in murine species. PD-1 and PD-1 ligands 1 and 2 (PD-L1 and PD-L2) are B7:CD28 family members that regulate T cell activation and peripheral tolerance. PD-L1 is initially produced with signal peptide (aa: 1-18) sequence, the removal of which yields the mature protein with a large extracellular (aa: 19-238) region that contains an Ig-like V-type domain (aa: 19-127) and an Ig-like C2-type domain (aa: 133-225), followed by a transmembrane domain (aa: 239-259) and a cytoplasmic tail (aa: 260-290). When engaged together with the TCR, the interaction of PD-1 with its ligands delivers an inhibitory signal to T cell proliferation and cytokine production. While PD-L1 is broadly expressed in hematopoietic and non-hematopoietic cells, PD-L2 expression is highly restricted to antigen presenting cells (APCs), including dendritic cells (DCs) and macrophages. The PD-1 pathway plays a key role in the progressive loss of effector T cell responses during chronic HIV infection. Tumor-associated PD-L1 is reported to facilitate apoptosis of activated T cells and stimulate IL-10 production in T cells to mediate immune suppression. These effects can be blocked by some monoclonal PD-L1 antibodies and T cell function can be restored. (Ref.: Chen, L., and Han, X (2015). J. Clin. Invest. 125(9): 3384-3391).
    Product Information
    Format Purified
    Presentation Purified rat monoclonal antibody IgG2b in PBS without azide.
    Quality Level MQ100
    Applications
    Application Detect PD-L1 using this rat monoclonal Anti-PD-L1 Antibody, clone 10F.9G2, Cat. No. MABC991. It has been tested in Flow Cytometry, Function Induction, Immunohistochemistry, and Inhibition studies.
    Key Applications
    • Flow Cytometry
    • Inhibition
    • Immunohistochemistry
    Application Notes Immunohistochemistry Analysis: A representative lot detected PD-L1 in Immunohistochemistry applications (Grabie, N., et. al. (2007). Circulation. 116(18):2062-71).

    Induces Function Analysis: Blockade with a representative lot of anti-PD-L1 combined with IL-2 enhanced antiviral CD8 T cell responses during chronic LCMV infection (West, E.E., et. al. (2013). J Clin Invest. 123(6):2604-15).

    Inhibition Analysis: A representative lot blocked the action of PD-L1 (Grabie, N., et. al. (2007). Circulation. 116(18):2062-71;West, E.E., et. al. (2013). J Clin Invest. 123(6):2604-15;El Annan, J., et. al. (2010). Invest Ophthalmol Vis Sci. 51(7):3418-23).
    Biological Information
    Immunogen CHO-mPD-L1 transfectants.
    Clone 10F.9G2
    Concentration Please refer to lot specific datasheet.
    Host Rat
    Specificity Clone 10F.9G2 specifically detects PD-L1 in murine EL4 lymphoma cells and targets the extracellular domain.
    Isotype IgG2bκ
    Species Reactivity
    • Mouse
    Species Reactivity Note Mouse.
    Antibody Type Monoclonal Antibody
    Entrez Gene Number
    Gene Symbol
    • CD274
    • B7h1
    • Pdcd1l1
    • Pdcd1lg1
    • Pdl1
    Purification Method Protein G purified
    UniProt Number
    Molecular Weight 32.78 kDa calculated.
    Product Usage Statements
    Quality Assurance Evaluated by Flow Cytometry in EL4 cells.

    Flow Cytometry Analysis: 1 µg/mL of this antibody detected PD-L1 in one million EL4 cells.
    Usage Statement
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    Storage and Shipping Information
    Storage Conditions Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    Packaging Information
    Material Size 100 μg

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