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文献和实验Combined MicroRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers
of protein markers, it is possible to precisely characterize the microRNA expressing cells and to identify the potential microRNA targets. This combined technology can also help to monitor changes in the level of potential microRNA targets in a therapeutic
Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy
TRAIL that indicates that, after intravenous injection, the majority of the protein is rapidly cleared. Increasing the in vivo half-life of recombinant soluble TRAIL or developing an alternative means of delivery may increase the relative tumoricidal
Biochemical Analysis of the Native TRAIL Death-Inducing Signaling Complex
years. For the CD95 and the TRAIL-R1/R2 DISCs, it is now clear that the adaptor protein Fas-associated DD protein (FADD) forms part of these complexes and is necessary for recruitment of the pro-apoptotic signaling molecules caspase-8 and caspase
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