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文献和实验radical is highly reactive, producing a variety of purine- and pyrimidine-derived lesions in DNA (2 ,3 ). A major pathway of hydroxyl radical-induced DNA damage involves attack on the C8 position of purines to produce 8-oxoG (7,8-dihydro-8-oxoguanine
Detection and Quantitation of Uracil DNA Glycosylase Activity
One of the main determining factors for maintaining the informational integrity of the DNA genomes in all organisms is the efficiency of repair of DNA lesions. DNArepair mechanisms have evolved to counteract the deleterious effects of DNA
Repair of A/G and A/8-oxoG Mismatches by MutY Adenine DNA Glycosylase
9 ). The E. coli MutY is an adenine glycosylase active on DNA containing A/GO, A/G, and A/C mismatches (7 ,10 –15 ) and also has a weak guanine glycosylase activity on G/GO-containing DNA (15a ,15b ). MutY removes misincorporated adenines paired
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