CMV pp65 protein.The protein contains the CMV pp65 immunodominantregions. It is fused to a 26kDa GST-tag. The protein is purified by proprietarychromatographic technique.The E.coli derived protein contains the CMV Pp65 immunodominant regions, 297-510 aa. It is fused to a GST tag.Human cytomegalovirus (HCMV), a member of the herpesvirus family, demonstrates cell specificity for virus assembly and release.CMVpp65 (UL83), in addition to being a major constituent of dense bodies, plays a critical role in cellmediated immunity to HCMV infection. The majority ofHCMV-seropositive individuals possess CD8+ cytotoxic Tlymphocyte responses directed against pp65, and theadoptive transfer of pp65-specific cytotoxicT lymphocytes isolated from HCMV-seropositive bone marrow donors to transplant recipients has been shown toconfer protection against HCMV viremia and pneumonitis. These observations have provided support for the concept of development of pp65 vaccines for prevention ofHCMV infection.
产品名:CMV pp65 protein,orb73437,Biorbyt
货号:orb73437
产品中文名:CMV pp65 protein
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