JW74， 863405-60-1，SML0227-5MG

应用
JW74 has also been used to test its efficacy in concurrent radiation and cisplatin (CDDP)-mediated cytotoxicity using HeLa and cervical carcinoma SiHa cell lines.[1] It has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.[2]
JW74 has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.[2]

生化/生理作用
JW74 is a tankyrase inhibitor of β-catenin-mediated Wnt signaling activity.[3] It degrades β-catenin by stabilizing axis inhibition protein (AXIN), a component of the β-catenin degradation complex.[2] It reduces cell cycle progression and induces caspase-3 mediated cell apoptosis in osteosarcoma cells.[3]
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW74 affects the multiprotein complex consisting of b-catenin/GSK-3b/AXIN/APC /CK1 that controls the degradation of b-catenin. JW74 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase. JW74 also inhibits tumor formation and growth in the small intestine and colon of ApcMin mice.