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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Rosuvastatin hemicalcium; ZD 4522 Calcium
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥292.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥132.0 |
| 规格： | 5 mg | 产品价格： | ￥265.0 |
| 规格： | 10 mg | 产品价格： | ￥400.0 |
| 规格： | 50 mg | 产品价格： | ￥600.0 |
| 规格： | 100 mg | 产品价格： | ￥1040.0 |
| 规格： | 200 mg | 产品价格： | ￥1580.0 |
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Rosuvastatin Calcium
CAS No. : 147098-20-2
MCE 国际站：Rosuvastatin Calcium
产品活性：Rosuvastatin Calcium 是一种竞争性 HMG-CoA 还原酶 (HMGCR) 抑制剂，IC50 为11 nM。Rosuvastatin Calcium 有效阻断 hERG 电流，IC50 为 195 nM。Rosuvastatin Calcium 降低成熟 hERG 的表达以及热休克蛋白 70 (Hsp70) 与 hERG 蛋白的相互作用。Rosuvastatin Calcium 有效降低低密度脂蛋白 (LDL) 胆固醇，甘油三酯和 C- 反应蛋白水平。
研究领域：Metabolic Enzyme/Protease | Autophagy | Membrane Transporter/Ion Channel | Anti-infection
作用靶点：HMG-CoA Reductase (HMGCR) | Autophagy | Potassium Channel | Bacterial
In Vivo: Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms.
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin.
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