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文献和实验Assessment of Cellular Localization of the Thromboxane A2 Receptor by Immunocytochemistry
Transmembrane receptors play a crucial role in communication between cells. By coupling to intracellular proteins and second-messenger systems, these molecular entities allow for the transduction of a biochemical message across the cell
Whole Blood Assays for Evaluation of Thromboxane Synthase Inhibition
to generate thromboxane A2 (TXA2 ) in response to an agonist has been assessed, and similar assays figure importantly in the current clinical trials (4 ) of cyclooxygenase-2 (COX-2) inhibitors. Early work by Sun (5 ), carried out with human platelet
The release of arachidonic acid (AA) from membrane phospholipids by phospholipase A2 (PLA2 ) is a critical step in the generation of lipid mediators by mast cells. AA released by PLA2 activity is metabolized to bioactive compounds
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