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- 详细信息
- 文献和实验
- 技术资料
- 保质期：
1460
- 英文名：
Ionomycin (calcium salt)
- 库存：
大量
- 供应商：
Neobioscience
- CAS号：
56092-82-1
- 保存条件：
-20
- 规格：
1 mg
Ionomycin (calcium salt)产品货号11932，是一种钙离子载体，最初从聚合乳杆菌中分离。当以5 uM的浓度使用时，它诱导X. laevis卵母细胞中的细胞内钙动员。Ionomycin (calcium salt)(5 uM)诱导分离的人嗜中性粒细胞中嗜中性粒细胞细胞外陷阱(网)的形成。Ionomycin (calcium salt)与佛波醇12-肉豆蔻酸13-乙酸酯(PMA)通常用于体外诱导T细胞的增殖和活化，以及刺激巨噬细胞中细胞因子的产生。
Ionomycin is a calcium ionophore originally isolated from S. conglobatus.1 It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils.2 Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.3,4
WARNING This product is not for human or veterinary use.
产品结构：
产品详情
货号：11932
产品名称：Ionomycin (calcium salt)
CAS号：56092-82-1
分子式：C41H70O9 • Ca
分子量：747.1
纯度：>98%
形式：A crystalline solid
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文献和实验1. Liu, W.C., Slusarchyk, D.S., Astle, G., et al. Ionomycin, a new polyether antibiotic. J. Antibiot. (Tokyo) 31(9), 815-819 (1978).
2. Locke, M., Francis, R.J., Tsaousi, E., et al. Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin. Sci. Rep. 10(1), 11694 (2020).
3. Lehnert, C., Weiswange, M., Jeremias, I., et al. TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation. J. Immunol. 193(8), 4021-4031 (2014).
4. Foey, A.D., and Brennan, F.M. Conventional protein kinase C and atypical protein kinase Cζ differentially regulate macrophage production of tumour necrosis factor-ɑ and interleukin-10. Immunology 112(1), 44-53 (2004).
at lower salt concentrations, whereas many primer pairs producing short amplification products worked better at higher salt concentrations. This is illustrated in the three figures below in which there is a realtive shift in the intensity of the products
The presence of a redundant lipolytic system of bile salt-activated lipase (BAL) and pancreatic lipase results in the concerted action of these lipolytic enzymes during intestinal dietary fat digestion processes (1 ). Because of its wide
盐腺 salt gland （ 1）为海产软骨鱼类、爬行类和鸟类的 NaCl分泌腺，在软骨鱼类有开口于直肠的直肠腺，在爬行类和鸟类有，开口于鼻腔的鼻腺，龟的开口于眼窝的泪腺，已变为盐腺。盐腺的分泌液主要含 NaCl，排出比海水浓度还要大的溶液。分泌细胞中有大量的线粒体，与哺乳类的肾小管细胞的构造非常相似。 Na－ K－ ATP 酶活性高。用海水养鸭时，其盐腺可发达增大数倍。 （ 2）指树苗（主要是叶）向表面分泌盐类的构造。亦称钙腺。盐腺的构造因种属而异
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