TRAF2 Monoclonal Antibody (Clo

Antigen: fusion protein corresponding to amino acids 205-222 of human TRAF2 • Host: mouse • Cross Reactivity: (+) human TRAF2 • Application(s): WB • TRAF2, an adaptor protein that mediates signal transduction from TNF receptors, is involved in cellular resistance to TNF-induced apoptosis. Mutagenic studies suggest that the N-terminal RING finger and two adjacent zinc fingers of TRAF2 are required for NF-κB activation, whereas interaction with TNFR is mediated through the C-terminal domain. Distinct domains in the N- and C-termini are also required for association with TRAF1 and protein kinase receptor interacting protein (RIP).