相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 国食药监械注册号:
无
- 库存:
100
- 供应商:
上海玉研科学仪器有限公司
- 现货状态:
现货供应 大小鼠动态足底触觉仪
- 保修期:
1年 大小鼠动态足底触觉仪
- 规格:
敬请来电咨询
动态足底触觉仪是评估大鼠、小鼠足底对触觉敏感性的测试设备。
动物模型的刺痛测试与分析在药物诊断、神经病理学和机体损伤性研究等多种研究领域有着广泛的应用。

型号:37550
主要特色
· 自动检测动物反应,无需人为判断;
· 可调节施加力的测试速率;
· 带统计和分析软件;
· 可通过U盘进行数据拷贝;
· 可选配打印机对数据进行打印;
· 可选配鼠筒可进行口部、面部刺激

测试主机

触觉刺激器

测试主机显示面板
主要配置
· 便携和易用移动的触觉刺激器,配有刚性探针和可调节角度的镜子;
· 控制主机,带触控屏,显示直观,操作方便;
· 十字孔板测试平台;
· 模块化动物鼠笼:使用隔板可分配成3个大鼠鼠笼和12个小鼠鼠笼测试单元;

电控型测试探针

测试平台

十字测试网格
设备的操作
· 大鼠、小鼠被放置到测试平台上,用测试鼠笼约束;
· 受试动物在鼠笼内科自由活动;
· 给出一定的环境适应时间和老鼠的探索时间;
· 操作人员将触觉刺激器放置在动物爪子正下方,在反光镜的帮助下定位硬丝;
· 启动触觉刺激器的按钮开始测试;
A:刚性探针被自动抬高;
B:探针接触足底后,开始施力;
C:力度以预设施力速率增加,直到动物移除爪子或达到预设力度,自动停止加力;
· 自动记录两个测试指标:缩爪的潜伏期(单位:S)和缩爪时的力度(单位:g)
数据的采集
· 测试主机可直观显示测试数据,并对数据进行存储;
· 数据可导出到电脑,或者使用专用U盾进行数据拷贝;
· 通信由基于CUB Data Acquisition Windows®的专用软件包52050-10管理;
· 能够将实验数据传送到电脑并使用常用软件进行管理;
· 配备了存储键,用于记录回顾实验数据;
· 支持使用远程网络连接测试主机,对实验参数进编辑;
参考文献:
l R. Lu, A. Schmidtko: “Direct Intrathecal Drug Delivery in Mice for Detect-ing In Vivo Effects of cGMP on Pain Processing” Methods in Molecular Biology 1020: 215-221, 2013
l I.Q. Russe et alia: “Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception” Journal of Pain 2, 2013
l J. Btesh et alia: “Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia” J. Neuroscience 33 (21): 9184-9193, 2013
l V. Brázda et alia: “Dynamic Response to Peripheral Nerve Injury Detected by In Situ Hybridization of IL-6 and its Receptor mRNAs in the Dorsal Root Ganglia is not Strictly Correlated With Signs of Neuropathic Pain” Molecular Pain 9(42), 2013
l D. Piomelli et alia: ”Anandamide Suppresses Pain Initiation Through a Peripheral Endocannabinoid Mechansmsm” Nature NSC , 2010
l P.J. Austin et alia: “G. Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats” JoVE 61, e3393, doi:10.3791/3393, 2012




敬请来电咨询。
敬请关注玉研仪器微信号:

风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
- 作者
- 内容
- 询问日期
文献和实验1.Friščić, Jasna, et al. "The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts." Immunity 54.5 (2021): 1002-1021. doi:10.1016/j.immuni.2021.03.003
IF 43.47
2.Boyd, Jacob T., et al. "Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions." Nature metabolism 3.6 (2021): 762-773.doi:
IF 19.87
3.Defaye, Manon, et al. "The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain." The Journal of clinical investigation 132.12 (2022).doi: 10.1172/JCI154317
IF: 19.46
4.Liu, Shijia, et al. "Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions." Neuron 110.5 (2022): 857-873. doi:10.1016/j.neuron.2021.11.029
IF 18.69
5.Powell, Rasheen, et al. "Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior." Nature Communications 12.1 (2021): 5812. 10.1038/s41467-021-26100-6
IF 17.69
6.Cheong, Hogyun, et al. "Sutureless neurorrhaphy system using a macrophage-polarizing in situ visible light-crosslinkable adhesive protein hydrogel for functional nerve regeneration." Chemical Engineering Journal 445 (2022): 136641.
doi:10.1016/j.cej.2022.136641
IF 16.74
7.Llorca-Torralba, Meritxell, et al. "Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons." Brain 145.1 (2022): 154-167. doi: 10.1093/brain/awab239
IF 15.26
8.Sohn, Hee Su, et al. "Tolerogenic nanoparticles induce type II collagen–specific regulatory T cells and ameliorate osteoarthritis." Science Advances 8.47 (2022): eabo5284.doi: 10.1126/sciadv.abo5284
IF: 14.96
9.Fotio, Yannick, et al. "NAAA-regulated lipid signaling governs the transition from acute to chronic pain." Science advances 7.43 (2021): eabi8834.doi:10.1126/sciadv.abi8834
IF: 14.96
10.Kolbinger, Anja, et al. "Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation." EMBO Molecular Medicine 15.2 (2023): e16796.doi:
IF 14.26
11.Li, Jun, et al. "A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABAARs." Theranostics 11.12 (2021): 5970.doi:10.7150/thno.58364
IF 11.60
12.Pató, Anna, et al. "Hydrogen peroxide production by epidermal dual oxidase 1 regulates nociceptive sensory signals." Redox Biology (2023): 102670.doi: 10.1016/j.redox.2023.102670
IF 10.79
13.Tagne, Alex Mabou, et al. "Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain." Pharmacological Research 167 (2021): 105545. doi:10.1016/j.phrs.2021.105545
IF 10.33
14.Borgonetti, Vittoria, and Nicoletta Galeotti. "Combined inhibition of histone deacetylases and BET family proteins as epigenetic therapy for nerve injury-induced neuropathic pain." Pharmacological Research 165 (2021): 105431.doi: 10.1016/j.phrs.2021.105431
IF 10.33
15.Pohóczky, Krisztina, et al. "Discovery of novel targets in a complex regional pain syndrome mouse model by transcriptomics: TNF and JAK-STAT pathways." Pharmacological research 182 (2022): 106347.doi:10 .1016/j.phrs.2022.106347
IF 10.33
16.Huang, Junting, et al. "An orbitofrontal cortex to midbrain projection modulates hypersensitivity after peripheral nerve injury." Cell reports 35.4 (2021): 109033. 10.1016/j.celrep.2021.109033
IF 10.00
17.Dansereau, Marc-André, et al. "Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity." Journal of neuroinflammation 18.1 (2021): 1-18.doi: 10.1186/s12974-021-02125-y
IF 9.59
18.Na, Hyun Sik, et al. "Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model." Journal of Translational Medicine 20.1 (2022): 1-12. doi:10.1186/s12967-022-03515-3
IF 8.44
19.Flauaus, Cathrin, et al. "Slick Potassium Channels Control Pain and Itch in Distinct Populations of Sensory and Spinal Neurons in Mice." Anesthesiology 136.5 (2022): 802-822.doi: 10.1097/ALN.0000000000004163
IF 8.99
大小鼠转棒仪该仪器用于研究药物对动作协调性和抗疲劳特性的影响,对相关药物筛选有重要价值。实验时将动物放置在滚筒上并避免滑落,转动滚筒后,如果动物滑落下来就会相应停止下面的传感平台进行结果记录,可以同时进行五个大鼠或小鼠实验,大鼠采用直径3.75英寸的滚筒,小鼠采用直径为1.25英寸的滚筒。仪器采用数字控制: 5个标准通道,测试时间可调; 启动速度可调,最终速度可调; 加速度可调,前进反转两种模式选择; 测量距离可记录,标准计算机打印口输出; RS232 串口输出。大小鼠疲劳测试仪
技术资料








