Y-27632 . dihydrochloride（小分子化

产品名称：Y-27632 . dihydrochloride
货号：ALX-270-333-M025
规格：25mg

Y-27632 . dihydrochloride产品简介：

High potency inhibitor of smooth muscle contractions
Applications in nephrology, stem cell studies, cardiovascular, cancer, and neurology
Highly cited

Y-27632 is a highly potent, cell permeable, selective and ATP competitive inhibitor of ROCK1 and ROCK2 (IC50=800nM). It acts as a potent inhibitor of agonist-induced Ca2+sensitization of myosin phosphorylation and smooth muscle contractions, blocking cell spreading and suppresses RhoA-induced formation of stress fibers in hepatic stellate cells. Y-27632 significantly reduces the increase of inflammatory cytokines after reperfusion, preventing the development of acute renal failure. There are numerous application for this compound including: cardioprotective effects, suppression of tumor cell invasion, inhibition of superoxide production, mimicking effect of β-agonists on human cells, and an antinociceptive effect.

There has been a growing interest in Y-27632 for use in stem cell self-renewal and reprogramming. It is known to increase the survival rate of human embryonic stem cells undergoing cryopreservation.
Product Details
Alternative Name: (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl

Formula: C14H21N3O . 2HCl

MW: 247.3 . 73.0

CAS: 129830-38-2

Purity: ≥98% (HPLC (UV))

Purity Detail: Enantiomeric excess ≥96%

Identity: Determined by MS and NMR.

Appearance: White to pale yellow powder.

Solubility: Soluble in DMSO (25mg/ml), methanol (25mg/ml), acetonitrile (<1mg/ml), dioxan (<1mg/ml), water (very soluble).

Shipping: Ambient

Long Term Storage: -20°C

Use/Stability: Stock solutions are stable for up to 1 month when stored at -20°C.

Handling: Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.

Regulatory Status: RUO - Research Use Only

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