DIBAC4(3) (BIS-(1,3-DIBARBITUR

DiBAC4(3)是所谓的转化膜电位染料，当膜电位变化时可在细胞膜上重新分布。染料进入细胞膜是细胞膜去极化后染料的荧光性增强。染料对膜电位变化的荧光响应速度通常低于苯乙烯基染料di-4-ANEPPS，但是前者的荧光变化明显快于后者。DiBAC4(3)的新型潜在的非常重要的应用是在高通量药物筛选。

DiBAC₄(3) (Bis-(1,3-Dibarbituric acid)-trimethine oxanol) is a so-called translational membrane potential dye that redistributes within the cell membrane when membrane potential changes (1,2). The fluorescence of the dye is enhanced when the dye enters the cell membrane as a result of membrane depolarization. The rate of fluorescence response of the dye to membrane potential change is usually slower than that of the styryl dye di-4-ANEPPS, but the fluorescence signal change for the former is significantly larger than for the latter dye. DiBAC₄(3) has applications in high-throughput drug screening.

• λ_Ex/λ_Em (MeOH) = 493/516 nm
• Orange solid soluble in DMSO or DMF
• Store at -20°C and protect from light
• C₂₇H₄₀N₄O₆
• MW: 519
• [70363-83-6]