- ￥100
- Gene Operation
- USA
- ISH1007-0005MG
- 2025年11月07日
企业认证
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保质期：
2 years
- 英文名：
JK184
- 库存：
10
- 供应商：
上海伟进生物科技有限公司
- CAS号：
315703-52-7
- 保存条件：
-20℃
- 规格：
5mg
Biological Activity
JK184, a cell-permeable imidazopyridine derivative compound, is a potent downstream hedgehog (Hh) signaling antagonist that inhibits Shh-N-mediated Gli-transcription (IC50= 30 nM) and shows suppression of GLI1 and Ptch1 mRNA expression in a dose-dependent manner. JK184 has been found to function by inhibiting class IV alcohol dehydrogenase (Adh7), with an IC50 of 210 nM. JK184 exhibits antiproliferation activities in a wide range of cancer cell lines with abnormally activated Hh signaling (GI50= 3-21 nM) as well as in human xenografts in vivo [1]. JK184 is shown to modulate Hedgehog target gene expression by depolymerizing microtubules [2].
Chemical Properties
| Cas No.: 315703-52-7 |
M. Wt.: 350.44 |
| Formula: C19H18N4OS |
Purity: ≥98% |
| Synonym: Hh Signaling Antagonist VII |
|
| Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-y l)-2-thiazolamine |
|
| Appearance: Beige solid |
|
| Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol |
|
| Storage: Store solid at +4 ºC |
|
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
