PD 123319

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PD 123319

CAS No. : 130663-39-7

MCE 国际站：PD 123319

产品活性：PD 123319是血管紧张素II受体拮抗剂，IC50为34 nM。

研究领域：GPCR/G Protein

作用靶点：Angiotensin Receptor

In Vitro: PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. ¹²⁵I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC₅₀ of 92.9 nM) for DuP-753. PD-123319 does not have any effect on ¹²⁵I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC₅₀ of 6.9 nM, and has a much lower affinity for DuP-753 (IC₅₀ around 10 microM). 

相关产品：Angiotensin II human  |  Losartan  |  Telmisartan  |  Valsartan  |  Tranilast  |  A 779  |  Buloxibutid  |  AVE 0991  |  Candesartan  |  Irbesartan  |  YS-49  |  Nitrosoglutathione  |  Olmesartan  |  Olodanrigan  |  PD 123319 ditrifluoroacetate  |  CGP-42112  |  Talfirastide acetate  |  Alamandine  |  Azilsartan medoxomil  |  Angiotensin II 5-valine  |  Sparsentan  |  TRV-120027 TFA  |  Angiotensin III, human, mouse

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds