Polycomb & Trithorax复合物靶基因PCR基

Product	Species	Technology	Cat. No.
Polycomb & Trithorax Target Genes PCR Array	Human	Gene Expression	PAHS-505Z
Polycomb & Trithorax Target Genes PCR Array	Mouse	Gene Expression	PAMM-505Z
Polycomb & Trithorax Target Genes PCR Array	Rat	Gene Expression	PARN-505Z

Polycomb & Trithorax复合物靶基因PCR基因芯片可以同时检测被Polycomb & Trithorax复合物调控的84个关键基因的表达。Polycomb & Trithorax复合物通过组蛋白修饰进行表观遗传调控，调节细胞类型特异性基因的表达，对维持细胞特征非常重要。Polycomb & Trithorax复合物的活性控制着胚胎多能干细胞分化机制的诱导。它们活性的失调造成细胞特性改变，细胞分化和增殖基因的错误表达，并促成肿瘤发生。利用实时定量PCR，研究者可以方便并且可信地研究对被Polycomb和Trithorax复合物调控的重要靶基因进行同时检测。

Cellular Mechanisms:
Differentiation: BMP2, CADM1 (TSLC1), CCND2, CHST11, DHH, DKK1, EFNB1, EPHA4, EPHB3, FOXA2 (HNF3B), GATA2, GATA6, HAND1, HES1, IL6R, IRX3, JUN, KLF4, OTX2, PDGFRA, PMP22, RARB, SALL1, SOX17, THPO, TRIM10, TRIM15, UCP1, WNT5A.
Signal Transduction: BMP2, CDC42EP1, CDKN1A (p21CIP1/WAF1), CHST11, CXCL16, CXCR7, DKK1, DKK2, EPHA4, EPHB3, GAS6, HES1, HEY1, IGFBP1, IL6R, IRS4, JUN, OTX2, PDGFRA, PRKCH, PRKG2, PTPRA, RARB, RASD1, RASSF1, SMOC2, SOX17, TACSTD2, TCF7, TNFRSF19, WNT5A. Cell Cycle: BMP2, CCND2, CDKN1A (p21CIP1/WAF1), DHH, ESX1, G0S2, JUN, RASSF1.
Apoptosis: CADM1 (TSLC1), CDKN1A (p21CIP1/WAF1), CHST11, GATA6, IL6R, JUN, RARB, RYBP, SERPINB2 (PAI-2), TNFRSF19.
Extracellular Matrix Organization: CTSA, LOX, PDGFRA, TIMP3.
Chromatin Modification: BMI1 (PCGF4), CBX8, HMGN2, RBBP7. Other: CDH11, CYP1B1, DGAT2, FAM65A, HS3ST1, HS6ST2, MGLL, MYO5B, NID2, NPTX1, THBD, TMEM66, USP3, VSNL1.
Cellular Functions:
Transcription Factors: ATF3, ESX1, FOXA2 (HNF3B), GATA2, GATA3, GATA4, GATA6, HAND1, HEY1, HOXA10, HOXA5, IRX3, JUN, KLF4, MEIS2, OTX2, RARB, SALL1, SATB1, TRIM15, TSHZ1.
Transporters: KCNA1, SLC30A4, SLC34A2, TRPM3, UCP1