- ￥3000 - 3999
- Abbiotec
- 美国
- 254005
- 2025年11月06日
- E, WB, ICC
- Rabbit
- H, M, R
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within human RNAse H2A.
- 亚型：
Rabbit Ig
- 形态：
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆
- 标记物：
见下方详细说明
- 适应物种：
H, M, R
- 宿主：
Rabbit
- 应用范围：
E, WB, ICC
- 浓度：
见详细说明信息
- 靶点：
RNAse H2A
- 抗体英文名：
RNAse H2A Antibody
- 抗体名：
RNAse H2A Antibody
- 规格：
0.1 mg
RNAse H2A Antibody产品详细介绍：
| 产品名称： | RNAse H2A Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 254005 |
| 规格： | 0.1 mg |
| 产品描述： | Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within human RNAse H2A. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, ICC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500 |
| 别名： | Rnse H2A; Ribonuclease H2 subunit A; RNAse HI large subunit; Aicadi-Goutieres; syndrome 4 protein; AGS4 |
| 形态： | Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验Preparation of Recombinant RNase Single-Chain Antibody Fusion Proteins
Selective cytotoxicity is an important goal of specific drug targeting. Toward this end, toxins isolated primarily from higher plants and bacteria have been coupled to monoclonal antibodies (MAbs) and evaluated for their clinical efficacy
Construction and Characterization of RNase-Based Targeted Therapeutics
Cell targeting agents such as antibodies, antibody fragments (sFvs), or growth factors have been conjugated or genetically fused to a variety of plant and bacterial toxins. These targeted therapeutics, termed “immunotoxins
Inducing RNAi with siRNA Cocktails Generated by RNase III
by an RNase III-like endoribonuclease (Dicer) producing siRNAs that are 21-23 bp in length and contain 3' dinucleotide overhangs with 5'-phosphate and 3'-hydroxyl termini. These siRNAs mediate degradation of homologous transcripts, leading to gene silencing
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