- ￥3000 - 3999
- Abbiotec
- 美国
- 253096
- 2025年12月12日
- WB, IHC
- Mouse
- H
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified recombinant fragment of human NACC1 expressed in E. coli.
- 亚型：
Mouse IgG1
- 形态：
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
- 保存条件：
Store at -20°C
- 克隆性：
单克隆
- 标记物：
见下方详细说明
- 适应物种：
H
- 保质期：
1-2年
- 抗原来源：
Purified recombinant fragment of human NACC1 expressed in E. coli.
- 目录编号：
253096
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Mouse
- 应用范围：
WB, IHC
- 浓度：
见详细说明信息
- 靶点：
NACC1 (6H2)
- 抗体英文名：
NACC1 (6H2) Antibody
- 抗体名：
NACC1 (6H2) Antibody
- 规格：
0.1 ml
NACC1 (6H2) Antibody产品详细介绍：
| 产品名称： | NACC1 (6H2) Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 253096 |
| 规格： | 0.1 ml |
| 产品描述： | NAC1 (Nucleus accumbens-1) is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors. NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells and specifically co-represses other POZ/BTB proteins in the central nervous system. NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene. The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway. NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4. NAC1 is overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. |
| 克隆类型： | Mouse Monoclonal Antibody |
| 亚型： | Mouse IgG1 |
| 免疫原： | Purified recombinant fragment of human NACC1 expressed in E. coli. |
| 适用物种： | H |
| 应用范围： | WB, IHC |
| 应用说明： | WB: 1:500-1:2000; IHC: 1:200-1:1000; |
| 别名： | Nucleus accumbens-associated protein 1; NAC-1; BTB/POZ domain-containing protein 14B; BTBD14B; NAC1; NACC1 |
| 形态： | Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件： | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 参考文献： |
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文献和实验Antibody Staining of Ovaries 1. Dissect ovaries in EBR 2. Transfer ovaries into an Eppendorf tube and add 100 µl devitellinizing buffer and 600-µl heptane 3. Agitate gently for 10 minutes
酶标抗体和酶-抗酶复合物的应用于免疫酶组化技术（APAAP法）
TBS缓冲液(pH7.6 0.05mol/L Tris-HCl)： Tris 30.25g，NaCl 40.0g，HCl 11ml，加蒸馏水溶解至500ml，调pH值至7.4～7.6。抗体稀释用含1％牛血清白蛋白的TBS。 ③ Mayer苏木精复染液：苏木精0.1g，钾明矾5g，柠檬酸0.1g，水合氯醛5g，碘酸钠0.02g，蒸馏水100ml。将苏木精、钾明矾和碘酸钠溶于蒸馏水，再加温搅拌溶解，加柠檬酸和水合氯醛，混合后煮沸5min，冷却后过滤备用。 ④ 纯丙酮 ⑤ McAb
原理 补体能使溶血素（抗绵羊红细胞抗体）致敏的绵羊红细胞（SRBC）发生溶血，当致敏的绵羊红细胞浓度恒定时，溶血程度与补体含量和活性呈正比例关系。因此，将新鲜待检血清做不同稀释后，与致敏红细胞反应，测定溶血程度，以50%溶血时的最小血清量判定终点，可测知补体总溶血活性。以50%溶血判断结果比100%溶血灵敏、准确。 材料 1.待检人血清：静脉抽血，待凝后立即分离血清进行测定或-70℃保存。 2.缓冲盐水（pH7.4）：取NaCl 75g，1mol/L HCl 177ml
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