- ￥3000 - 3999
- Abbiotec
- 美国
- 253580
- 2025年07月14日
- E, WB, ICC
- Rabbit
- H, M, R
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- 详细信息
- 询价记录
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within human IRE1p.
- 亚型：
Rabbit Ig
- 形态：
Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆
- 标记物：
见下方详细说明
- 适应物种：
H, M, R
- 保质期：
1-2年
- 抗原来源：
KLH-conjugated synthetic peptide encompassing a sequence within human IRE1p.
- 目录编号：
253580
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Rabbit
- 应用范围：
E, WB, ICC
- 浓度：
见详细说明信息
- 靶点：
IRE1p
- 抗体英文名：
IRE1p Antibody
- 抗体名：
IRE1p Antibody
- 规格：
0.1 mg
IRE1p Antibody产品详细介绍：
| 产品名称： | IRE1p Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 253580 |
| 规格： | 0.1 mg |
| 产品描述： | Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within human IRE1p. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, ICC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500 |
| 别名： | IRE1p ; Endoplasmic reticulum-to-nucleus signaling 1; ERN1 |
| 形态： | Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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IRE1p Antibody_IRE1p抗体
￥3000 - 3999
