Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a chloride channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia. GAT-1 is thought to play a key role in epileptogenesis.
克隆类型:
Rabbit Polyclonal Antibody
亚型:
Rabbit Ig
免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of rat GABA transporter (GAT) 1.
适用物种:
M, R
应用范围:
E, WB, IHC
应用说明:
E: 1:500-1:1,000; WB: 1:1,000; IHC: 1:100-1:200
别名:
Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1; Slc6a1; Gabt1, Gat-1, Gat1
形态:
Each vial contains 0.1 ml IgG in HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified by immunogen affinity chromatography.
保存条件:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.