Apoptosis-stimulating of p53 protein 2 (ASPP2) is a regulator that plays a central role in regulation of apoptosis and cell growth. ASPP2 regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. ASPP2 inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. ASPP2 impedes cell cycle progression at G2/M. The apoptosis-stimulating activity of ASPP2 is inhibited by its interaction with DDX42.
克隆类型:
Rabbit Polyclonal Antibody
亚型:
Rabbit Ig
免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ASPP2.