PROTEIN KINASE A, CATALYTIC SU

Antisense Oligonucleotides Targeting RI Subunit of Protein Kinase A: In Vitro and In Vivo Anti-Tumor Activity and Pharmacokinetics

cAMP-dependent protein kinase (PKA) is involved in various cellular functions such as cell proliferation, gene induction, and metabolism (1 ,2 ) and its regulatory subunits have been suggested as a drug target for cancer and other diseases

Determination of the Catalytic Activities of mTOR and Other Members of the Phosphoinositide-3-Kinase-Related Kinase Family

domain to that of phosphoinositide-3-kinase, these extremely large (>250 kDa) polypeptides function as serine/threonine protein kinases. The catalytic activities of these PIKK family members can now be measured in immune-complex kinase assays. This assay

DNA-Dependent Protein Kinase in Apoptosis

target proteins, one of which is the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). The antiapoptotic factor Bcl-xL can sequester cytochrome C and inhibit the formation of the caspase-9-Apaf-1 complex effectively blocking apoptosis