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原癌基因CBL2抗体

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产品详情

品牌: 进口/国产
货号: YK1760
抗体名: 原癌基因CBL2抗体
抗体英文名: Anti-C CBL
靶点: 电询
浓度: 1mg/1ml
应用范围: 详细电询
宿主: 电询
适应物种: Human, Mouse, Rat,
标记物: 电询
克隆性:
保存条件: -20 °C
亚型: IgG
规格: 0.2ml/200μg
C CBL; CBL C; Cas Br M (murine) ecotropic retroviral transforming sequence; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; Casitas B-lineage lymphoma proto-oncogene; CBL 2; cbl; CBL_HUMAN; CBL2; E3 ubiquitin protein ligase CBL; E3 ubiquitin-protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; Proto-oncogene c-CBL; RGD1561386; RING finger protein 55; RNF55; Signal transduction protein CBL.
温馨提示:不可用于临床治疗。

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兔抗人CCBL2 多克隆抗体 丁香通标准抗体
品牌:novus  货号:NBP1-87387  应用:免疫印迹,免疫细胞化学/免疫荧光,免疫细胞化学,免疫组化—石蜡切片  价格:询价 
  phospho-CBL2(Tyr731) Antibody Cat#:PL0301769 Isotype:Rabbit Polyclonal IgG Immunogen:PhosphoPeptide derived from human CBL2 around the phosphorylation site of Tyr731.   Purification: Immunogen affinity purifiedStorage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)Background:The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. Alternate Names:phospho-C CBL (Tyr731); CBL2 (phospho-Tyr731); CBL2 (phospho-Tyr731); p-CBL2 (Tyr731); p-CBL2 (Y731); C CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lympllabspl-0301769
  phospho-CBL2(Tyr731) Antibody Cat#:PL0301769 Isotype:Rabbit Polyclonal IgG Immunogen:PhosphoPeptide derived from human CBL2 around the phosphorylation site of Tyr731.   Purification: Immunogen affinity purifiedStorage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)Background:The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. Alternate Names:phospho-C CBL (Tyr731); CBL2 (phospho-Tyr731); CBL2 (phospho-Tyr731); p-CBL2 (Tyr731); p-CBL2 (Y731); C CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lympllabspl0301769
  phospho-CBL2(Tyr731) Antibody Cat#:PL0301769 Isotype:Rabbit Polyclonal IgG Immunogen:PhosphoPeptide derived from human CBL2 around the phosphorylation site of Tyr731.   Purification: Immunogen affinity purifiedStorage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)Background:The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. Alternate Names:phospho-C CBL (Tyr731); CBL2 (phospho-Tyr731); CBL2 (phospho-Tyr731); p-CBL2 (Tyr731); p-CBL2 (Y731); C CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lympl laboratoriespl0301769
  CBL2 Antibody Cat#:PL0301768 Isotype:Rabbit Polyclonal IgG Immunogen:Peptide derived from human CBL2.   Purification: Immunogen affinity purifiedStorage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)Background:This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia.  Alternate Names:C CBL; Cas-Br-M (murine) ecotropic retroviral transforming sepllabspl-0301768

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