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文献和实验Design of Gene Therapy Clinical Trials in CF Patients
On April 17, 1993, Crystal and co-workers initiated the first human gene therapy trial for cystic fibrosis (CF). In that study, a replication-deficient recombinant adenovirus encoding cystic fibrosis transmembrane conductance regulator (CFTR
Analysis of MicroRNA Length Variety Generated by Recombinant Human Dicer
blotting and employed this method to investigate cleavages generated by recombinant human Dicer in the synthetic miRNA precursors. We paid special care to visualize clearly the cleavages generated by the individual RNase III domains of Dicer
Recombinant Antigens in Viral Diagnosis
(CF) assays (2 ). Although these assays can be specific and reliable in the hands of an experienced laboratory worker, they suffer from several significant disadvantages. HI and CF assays are frequently very specific, but are relatively insensitive
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