XAV 939

1) Cat. No.: TRC-X744000; 2) Chemical Name: XAV 939; 3) CAS No.: 284028-89-3; 4) Mol. Formula: C14H11F3N2OS; 5) Mol. Weight: 312.31; 6) Packing Size: 25mg / 250mg; 7) Appearence: ; 8) Application Notes: A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.; 9) Synonym: 1,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one; NVP-XAV 939;; 10) Solubility: ; 11) Storage condition: ; 12) References: Huang, S. et al.: Nature, 461, 614 (2009); Wang, H. et al.: ACS Chem. Biol., 6, 192 (2011); Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009);