N-α-Tosyl-L-phenylalanylchloro

1) Cat. No.: TRC-T686000; 2) Chemical Name: N-α-Tosyl-L-phenylalanylchloromethane; 3) CAS No.: 402-71-1; 4) Mol. Formula: C17H18ClNO3S; 5) Mol. Weight: 351.85; 6) Packing Size: 500mg / 5g; 7) Appearence: ; 8) Application Notes: N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues. ; 9) Synonym: L-1-Chloro-3-tosylamidyl-4-phenyl-2-butanone; L-1-Chloro-4-phenyl-3-p-tolylsulfonamidobutan-2-one; L-1-Chloro-4-phenyl-3-toluene-p-sulfonamido-2-butanone; L-1-Tosylamide-2-phenylethylchloromethyl Ketone; L-1-Tosylamido-2-phenylethyl Chloromethyl Ketone; L-Tolylsulfonylphenylalanyl Chloromethyl Ketone; N-(p-Toluenesulfonyl)-L-phenylalanylchloromethane; N-Tosyl-L-phenylalaninechloromethane; N-Tosyl-L-phenylalanyl Chloromethyl Ketone; N-Tosyl-L-phenylalanylchloromethane; N-Tosylphenylalanine Chloromethyl Ketone; N-α-Tosyl-L-phenylalanylchloromethane; Nα-Tosyl-L-phenylalanine Chloromethyl Ketone; TPCK; Tosylphenylalanine Chloromethyl Ketone; Tosylphenylalanylchloromethane; α-N-Tosyl-L-phenylalanine Chloromethyl Ketone ; 10) Solubility: ; 11) Storage condition: ; 12) References: Jitkaew, S. et al.: J. Bio. Chem., 284, 27827 (2009); Kim, K. et al.: Biochem. Biophys. Res. Comm., 306, 954 (2003); Griscavage, J. et al.: Biochem. Biophys. Res. Comm., 215, 721 (1995)