Toceranib-d8

1) Cat. No.: TRC-T525502; 2) Chemical Name: Toceranib-d8; 3) CAS No.: ; 4) Mol. Formula: C22H17D8FN4O2; 5) Mol. Weight: 404.51; 6) Packing Size: 1mg / 10mg; 7) Appearence: ; 8) Application Notes: Labelled Toceranib, a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor. Toceranib exhibited activity against a variety of spontaneous malignancies in canine such as mast cell tumors, mixed mammary carcinomas, soft tissue sarcomas, and multiple myeloma.; 9) Synonym: 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl-d8)ethyl]-1H-pyrrole-3-carboxamide; 5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid (2-(Pyrrolidin-1-yl-d8)ethyl)amide; PHA 291639; SU 11654;; 10) Solubility: ; 11) Storage condition: ; 12) References: London, C.A. et al.: Clin. Cancer Res., 9, 2755 (2003); Zavodovskaya, R. et al.: Am. J. Vet. Res., 67, 633 (2006); Malone, E.K. et al.: Vet. Comp. Oncol., 8, 209 (2010);