PF 431396

1) Cat. No.: TRC-P218290; 2) Chemical Name: PF 431396; 3) CAS No.: 717906-29-1; 4) Mol. Formula: C22H21F3N6O3S; 5) Mol. Weight: 506.5; 6) Packing Size: 10mg / 100mg; 7) Appearence: ; 8) Application Notes: PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. ; 9) Synonym: N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide; N-Methyl-N-[2-[[[2-[(2-oxo- 2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide; PF 431396; ; 10) Solubility: ; 11) Storage condition: ; 12) References: Han, et al.: J. Biol. Chem., 284 13193 (2009), Allen, et al.: J. Med. Chem., 53 4332 (2010),