trans-Ned-19

1) Cat. No.: TRC-N388750; 2) Chemical Name: trans-Ned-19; 3) CAS No.: 1354235-96-3; 4) Mol. Formula: C30H31FN4O3; 5) Mol. Weight: 514.59; 6) Packing Size: 5mg / 50mg; 7) Appearence: Yellow Solid; 8) Application Notes: trans-Ned-19 is a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells. ; 9) Synonym: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid;; 10) Solubility: Methanol; 11) Storage condition: Refrigerator; 12) References: Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009); Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009); Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009);