Myriocin

1) Cat. No.: TRC-M884400; 2) Chemical Name: Myriocin; 3) CAS No.: 35891-70-4; 4) Mol. Formula: C21H39NO6; 5) Mol. Weight: 401.54; 6) Packing Size: 5mg / 50mg; 7) Appearence: ; 8) Application Notes: Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin is a useful biochemical research tool for depleting cells of sphingolipids.; 9) Synonym: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic Acid;; 10) Solubility: ; 11) Storage condition: ; 12) References: Miyake, Y., et al.: Biochem. Biophys. Res. Commun., 211, 396 (1995); Hidari, K.I.P.J. et al.: J. Biol. Chem., 271, 14636 (1996); Nakamura, S. et al.: J. Biol. Chem., 271, 1255 (1996); De Zélicourt, A. et al.: Planta 230, 1047 (2009);