MK-2048

1) Cat. No.: TRC-M425030; 2) Chemical Name: MK-2048; 3) CAS No.: 869901-69-9; 4) Mol. Formula: C21H21ClFN5O4 ; 5) Mol. Weight: 461.87; 6) Packing Size: 5mg / 10mg; 7) Appearence: ; 8) Application Notes: MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir. ; 9) Synonym: (6S)-2-(3-Chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide;; 10) Solubility: ; 11) Storage condition: ; 12) References: Tamara, B.M. et al.: J. Virol., 10, 1128 (2010);