1) Cat. No.: TRC-G797400; 2) Chemical Name: GSI-953; 3) CAS No.: 769169-27-9; 4) Mol. Formula: C9H8ClF6NO3S2; 5) Mol. Weight: 391.74; 6) Packing Size: 10mg / 100mg; 7) Appearence: ; 8) Application Notes: Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia. ; 9) Synonym: 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide; Begacestat; GSI 953; ; 10) Solubility: ; 11) Storage condition: ; 12) References: van Es., et al.: Nature, 435, 959 (2005), Morohashi., et al.: J. Biol. Chem., 281, 1467 (2006), O'Neil., et al.: Neoplasia, 107, 781 (2006), Mayer, et al.: J. Med. Chem., 51, 7348 (2008), Martone, et al.: J. Pharmacol. Exp. Ther., 331, 598 (2009),