(-)-trans-7,8-Dihydroxy-7,8-di

1) Cat. No.: TRC-D452280; 2) Chemical Name: (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; 3) CAS No.: 60864-95-1; 4) Mol. Formula: C20H14O2; 5) Mol. Weight: 286.32; 6) Packing Size: 2.5mg / 25mg; 7) Appearence: Brown Solid; 8) Application Notes: (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene (B205800). Benzo[a]pyrene (B205800), a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (D452280) undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen.; 9) Synonym: (-)-7,8-Dihydrobenzo[a]pyrene-7,8-diol; (-)-Benzo[a]pyrene-7R-trans-7,8-dihydrodiol; (-)-trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene; (-)-trans-7,8-Dihydrobenzo[a]pyrene-7,8-diol; (7R,8R)-7,8-Dihydro-benzo[a]pyrene-7,8-diol; 10) Solubility: Tetrahydrofuran; 11) Storage condition: -20°C Freezer; 12) References: Gelhaus, S. et al: Chem. Res. Toxicol., 24, 89 (2011); Belvedere, G. et al.: Biochem. Pharmacol., 29, 1693 (1980); Jennette, K. et al.: Biochem. Pharmacol., 28, 338 (1979); Yagi, H. et al.: J. Am. Chem. Soc., 99, 2358 (1977)